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CAS Number 13721-39-6

Linear Formula Na3VO4

Molecular Weight 183.91

EC Number 237-287-9

MDL number MFCD00003511

PubChem Substance ID 24899708

NACRES NA.77

 

Description

Application

Sodium orthovandate was used to prepare the stop solution in dephosphorylation assay of insulin receptor kinase.26 It was one of the reagents used in the development of Matrix ChIP that utilizes surface-immobilized antibodies.27

Packaging

10, 50, 250 g in poly bottle

Biochem/physiol Actions

Sodium orthovandate suppresses the activation of p53-mediated apoptosis triggered in response to radiation. It reduces the detrimental effects of hematopoietic syndrome, hematopoiesis and delayed genotoxic effects of induced by total body irradiation of mice.24 In combination with menadione, orthovandate prevents the migration of detached human glioma cells in response to anti-cancer drugs.25

Inhibits ATPase, alkaline phosphatase and tyrosine phosphatase. Decavanadate, which is formed at acidic pH, inhibits inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release from endocrine cells and blocks IP3 binding to its receptor in brain tissue.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Catalysis and Inorganic Chemistry, Cell Biology,

biological source synthetic (organic)
assay ≥90% (titration)
form crystalline powder
color white to off-white
mp 850-866 °C (lit.)
solubility H2O: soluble
SMILES string [Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O
InChI 1S/3Na.4O.V/q3*+1;;3*-1;
InChI key IHIXIJGXTJIKRB-UHFFFAOYSA-N
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