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دی اتیل استیل بسترول

Synonym: (E)-3,4-Bis(4-hydroxyphenyl)-3-hexene, DES, Stilbestrol

Description

Application

Diethylstilbestrol has been used:

  • to evaluate the estrogenic activity of diethylstilbestrol by quantitating the expression levels of endogenous estrogen-regulated marker genes[1]
  • to evaluate the estrogenic, androgenic and toxicity responses in bioluminescent yeast bioreporter assay (BLYES)[2]
  • to detect its effect on the proliferation and tyrosinase activity of melanocytes[3]

Biochem/physiol Actions

Diethylstilbestrol is a synthetic estrogen with carcinogenic properties. Causes renal clear-cell carcinoma in Syrian hamster. In humans it causes increased risk of breast cancer, clear cell adenocarcinoma (CCA) of the vagina and cervix, and reproductive anomalies. Used in the treatment of prostate cancer to block the production of testosterone.

Properties

Related Categories

Androgen Modulators, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cancer Research, Carcinogens,

Quality Level 200

assay ≥99% (HPLC)

SMILES string CC\C(c1ccc(O)cc1)=C(\CC)c2ccc(O)cc2

InChI key RGLYKWWBQGJZGM-ISLYRVAYSA-N

Gene Information human … ESR1(2099), ESR2(2100), ESRRG(2104) mouse … Esr1(13982)rat … Ar(24208), Esr1(24890)

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